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Plants utilise ancient conserved peptide upstream open reading frames in stress-responsive translational regulation



编号 040034403

推送时间 20220523

研究领域 森林培育 

年份 2022 

类型 期刊 

语种 英语

标题 Plants utilise ancient conserved peptide upstream open reading frames in stress-responsive translational regulation

来源期刊 Plant,Cell & Environment

第344期

发表时间 20220206

关键词 5′‐leader;5′‐UTR;  abiotic stress;Arabidopsis;CPuORF;ribosome stalling;  translation
regulation;uORF; 

摘要 The regulation of protein synthesis plays an important role in the growth and development of all organisms. Upstream open reading frames (uORFs) are commonly found in eukaryotic messenger RNA transcripts and typically attenuate the translation of associated downstream main ORFs (mORFs). Conserved peptide uORFs (CPuORFs) are a rare subset of uORFs, some of which have been shown to conditionally regulate translation by ribosome stalling. Here, we show that Arabidopsis CPuORF19, CPuORF46 and CPuORF47, which are ancient in origin, regulate translation of any downstream ORF, in response to the agriculturally significant environmental signals, heat stress and water limitation. Consequently, these CPuORFs represent a versatile toolkit for inducible gene expression with broad applications. Finally, we note that different classes of CPuORFs may operate during distinct phases of translation, which has implications for the bioengineering of these regulatory factors.

服务人员 孙小满

服务院士 尹伟伦

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