Evolution and Functions of Plant U-Box Proteins From Protein Quality Control to Signaling

编号 040034405

推送时间 20220523

研究领域 森林培育 

年份 2022 

类型 期刊 

语种 英语

标题 Evolution and Functions of Plant U-Box Proteins From Protein Quality Control to Signaling

来源期刊 The Annual Review of Plant Biology

期 第344期

发表时间 20220228

关键词 U-box domain；stress responses；ubiquitination；phosphorylation；crosstalk; 

摘要 Posttranslational modifications add complexity and diversity to cellular proteomes. One of the most prevalent modifications across eukaryotes is ubiquitination, which is orchestrated by E3 ubiquitin ligases. U-box-containing E3 ligases have massively expanded in the plant kingdom and have diversified into plant U-box proteins (PUBs). PUBs likely originated from two or three ancestral forms, fusing with diverse functional subdomains that resulted in neofunctionalization. Their emergence and diversification may reflect adaptations to stress during plant evolution, reflecting changes in the needs of plant proteomes to maintain cellular homeostasis. Through their close association with protein kinases, they are physically linked to cell signaling hubs and activate feedback loops by dynamically pairing with E2-ubiquitin-conjugating enzymes to generate distinct ubiquitin polymers that themselves act as signals. Here, we complement current knowledge with comparative genomics to gain a deeper understanding of PUB function, focusing on their evolution and structural adaptations of key U-box residues, as well as their various roles in plant cells.

服务人员 孙小满

服务院士 尹伟伦

PDF文件 浏览全文