数据资源: 林业前沿资讯

The chromatin-associated protein PWO1 interacts with plant nuclear lamin-like components to regulate nuclear size

编号 040018503

推送时间 20190506

研究领域 森林培育 

年份 2019 

类型 期刊 

语种 英文

标题 The chromatin-associated protein PWO1 interacts with plant nuclear lamin-like components to regulate nuclear size

第185期

发表时间 20190326

摘要 Spatial organization of chromatin contributes to gene regulation of many cellular processes and includes a connection of chromatin with the nuclear lamina (NL). NL is a protein mesh that resides underneath the inner nuclear membrane (INM) and consists of lamins and lamina-associated proteins. Chromatin regions associated with lamins in animals are characterized mostly by constitutive heterochromatin, but association with facultative heterochromatin mediated by Polycomb-group (PcG) proteins has been reported as well. In contrast to animals, plant NL components are largely not conserved and NL association with chromatin is poorly explored. Here, we present the connection between lamin-like protein, CROWDED NUCLEI 1 (CRWN1), and the chromatin- and PcG-associated component, PWWP INTERACTOR OF POLYCOMBS 1 (PWO1), in Arabidopsis thaliana. We show that PWO1 and CRWN1 proteins associate physically with each other, act in the same pathway to maintain nuclear morphology and control expression of a similar set of target genes. Moreover, we demonstrate that PWO1 proteins forms foci located partially at the subnuclear periphery. Ultimately, as CRWN1 and PWO1 are plant-specific, our results argue that plants might have developed an equivalent, rather than homologous, mechanism of linking chromatin repression and nuclear lamina.

服务人员 孙小满

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